Jason Roberts, Doherty Institute The cure for hepatitis C, developed in the last decade, sparked renewed hope that the milestone can be duplicated in hepatitis B. “We are committing everything we have, every resource at our disposal, to developing the therapies that will ultimately improve the lives of all people living with hepatitis B worldwide and ultimately relegate hepatitis B to the history books.”, Drugs currently in development at the Blumberg Institute. We have screened thousands of plant and fungal extracts from our extensive Natural Products Collection and identified two new leads that show potential activity against HBV. The Baruch S. Blumberg Institute of the Hepatitis B Foundation is at the forefront of research efforts to discover such new drugs. 2. Anyone who has a sexually tr… Among the products in the pipeline: We are among the first, if not the only group, to identify the first small molecule inhibitor of HBV cccDNA, which has now been made highly active and is licensed to Arbutus Biopharma for further development. If you think you have been exposed to infected blood or body fluids, see a doctor as soon as possible. Newborns 2. Show all parts of this monograph; Indications and dose; Important safety information; Contra-indications; Cautions ; Side-effects; Allergy and cross-sensitivity; Pregnancy; Breast feeding; Directions for administration; Handling and storage; Medicinal forms; Indications and dose. In another innovative approach, researchers are screening plant and fungal extracts from its Natural Products Collection, donated by Merck & Co. in 2011, and have already discovered two potential drugs that are active against hepatitis B. However, there are millions who do not benefit and are still left vulnerable. How far are we from finding a cure for hepatitis B? Routine infant immunization against hepatitis B has increased globally with an estimated coverage (third dose) of 84% in 2017. The hepatitis B vaccine is the mainstay of hepatitis B prevention. 4. Learning the Hep B Basics, B Informed Conference Videos and Information, Coalition Against Hepatitis for People of African Origin, Externally Led Patient-Focused Drug Development Meeting. HBV can be a short-term (acute) or a long-term (chronic) illness: Acute HBV occurs within 6 months after a person is exposed to HBV. New tool launched to assist people living with hepatitis B in making decisions on health insurance <>, From the Spring 2016 B Informed Newsletter. Stay connected to friends and family. Discontinuation of long-term nucleoside/nucleotide antiviral treatment for hepatitis B can allow some people to achieve a cure, according to a pair of presentations last week at the 2020 Digital International Liver Congress.This may happen because the flares of viral replication and inflammation that can occur when the drugs are stopped induces durable immune control of the virus. Experts believe a cure for hepatitis B will also soon be developed. Chronic hepatitis B infection, a lifetime disease with no effective cure, could one day be cleared from a person’s system with a series of shots, according to a new USC study. In the UK it is estimated that about 1 person in 200 to 1,000 is infected with the hepatitis B virus. Bud Tennant Leaves Behind a Distinguished Scientific Legacy, Nationwide Hepatitis Delta Virus (HDV) Campaign, CMS Final Decision to Cover Hepatitis B Screening, Pennsylvania Biotechnology Center’s Kassa named one of The 10 Best COOs of 2020, Hepatitis B community leaders convene to address eliminating hepatitis B during COVID-19 pandemic, Current and Past "B Informed" Newsletters. Antiviral medications seldom cure hepatitis B, however, and they may need to be taken long-term, like HIV treatment. The aims of hepatitis B treatment include stopping hepatitis B virus replication, reducing liver inflammation, and lowering the risk of developing cirrhosis or liver cancer. Hepatitis B and C are blood-borne infections, while hepatitis A is easier to catch, but less serious. Hepatitis C virus and hepatitis B can make an infected person very sick and they are risk factors for liver cancer, liver disease, liver failure, and liver damage. 3. But hope for a cure is growing. Prior to 1992, blood transfusion was a risk for contracting hepatitis C infection. 3805 Old Easton Road Despite this, research into HBV is drastically underfunded, to the point that it was recently compared to a neglected tropical disease. Hepatitis B is an infection of the liver caused by the hepatitis B virus (HBV). “Treatments are available,” explained Block, “but we have become a little too comfortable with the medications that are currently approved for use.” While these drugs are effective, interferon has many side effects and daily antivirals require lifelong use. These people become chronically infected with hepatitis B, meaning that they continue to be infectious – although they may not experience any symptoms at all, or not for many years. Health care workers, emergency workers and other people who come into contact with blood 6. He points out that hepatitis C, initially thought to be incurable, can now be cured with new combination treatments. Doylestown, PA 18902 In another innovative approach, researchers are screening plant and fungal extracts from its Natural Products Collection, donated by Merck & Co. in 2011, and have already discovered two potential drugs that are active against hepatitis B. Moreover, they work in only about half of the infected population, and reduce the rate of death due to liver disease by only about 40 to 70 percent. We are using high-throughput screens and computer modeling to design and produce targeted drugs that include capsid inhibitors for HBV and “YES kinase” inhibitors for liver cancer. “There has never been more optimism than right now that a cure is within reach,” says Block. Blumberg scientists have played a key role in increasing understanding of the virus life cycle and are designing and developing ways to test new drugs. Immune System Activators: It has developed a new HBV drug that works by activating an infected liver cell’s own immune system, which has been shown to be effective in animal studies. Because one-drug treatments can lead to drug resistance, a cure would almost certainly involve combination therapy. This is significant because inhibition of cccDNA is considered essential in achieving a complete cure. Initiate antiviral therapy as soon as possible. Doylestown, PA 18902 Adding to its drug arsenal, Blumberg researchers have used computer modeling to design and produce targeted drugs against hepatitis B and liver cancer. Hepatitis C is the No. Block is confident that a drug with this mechanism will eventually become available. Fax: 215-489-4920 Experts believe a cure for hepatitis B will also soon be developed. The available antivirals are similar and combining them offers no advantage. cccDNA Inhibitors: Blumberg is the only group to identify the first small molecule inhibitor of HBV cccDNA, which has now been made highly active and is licensed to Arbutus Biopharma for further development.